Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Although it picked up a best editing prize from the LA Film Critics Association, it was ignored by their New York counterparts. Could its momentum be waning?
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
“The Man Who Knew is an impressive work of scholarship,” Lionel Barber, editor of the FT and chair of the book award judges, said. “It’s a masterpiece of political economy and, above all, it’s a great and enjoyable read.”
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Based on a new estimate provided by the government of Dubai, its visitor spending of $31.3 billion this year far exceeds London's estimated $19.8 billion, which comes second.
Its Academic Ranking of World Universities is made up of six objective indicators, including the number of alumni and staff winning Nobel Prizes and Fields Medals, the number of highly-cited researchers, the number of articles published in the journals Nature and Science, the number of articles indexed in the "Science Citation Index", and their per capita performance.
The reason is twofold: For one, logistically, there are simply too many opportunities to get caught job searching. Résumé copies will be found. Computer servers will be checked. Co-workers will notice when you're clearly elsewhere, either literally for interviews or emotionally (more on that later)。
Trends and targets in antiviral phototherapy
As for the fortunes of the gig economy, the UK will be a key country to watch. The government is due to respond to an independent review into whether British law is keeping up with this new trend. Bold policy action — either in favour or against online labour platforms — now seems less likely given the fragility of the government and the time-consuming nature of Brexit.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
法国的巴黎高等商学院(HEC Paris)和法国高等经济商业学院(Essec Business School)连续第三年分列第二和第三。
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
当发生问题时，库克会迅速而无情地采取行动。2012年底，苹果过早推出了有缺陷的苹果地图(Apple Maps)应用之后，库克解雇了乔布斯的亲密盟友、领导开发iOS的斯科特?福斯托(Scott Forstall)，以及前Dixons首席执行官、掌管苹果零售部门不到一年的约翰?布劳伊特(John Browett)。此举传递出一条信息：库克不会容忍业绩不佳或内部政治。
ACE2 as a potential therapeutic target for pandemic COVID-19
Diagnostic technologies for COVID-19: a review
Please accept my season\'s greetings.
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
I can well imagine that in 2016 the oil price will bounce back from its current sub $40 level. The Saudis may try to cut production, there could be more conflict in Iraq, terrorists could attack some of the prize targets such as the oil terminals at Ras Tanura and Abqaiq. Anything is possible, something is likely. But the question is how far the bounce will go.
不过在这一通胡闹之余（主持人蒂娜?费举杯道：致这个美好的混乱之夜），本届金球奖(Golden Globes)颁奖典礼还是清醒地把多项重要大奖颁给了各个夺奖热门。戴维?罗素(David O. Russell)电影作品《美国骗局》(American Hustle) 揽入包括最佳喜剧片在内的三项金球奖，成为当晚最大赢家。历史剧情片《为奴十二年》(12 Years a Slave)虽在另外六个竞赛单元中失利，但最终斩获了最佳剧情片奖。
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
The clip, taken on a mobile phone, starts with the crowd singing the Frankie Valli lyrics: You're just too good to be true, can't take my eyes off of you'.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
Pink, LeBron James, Selena Gomez, Ian Somerhalder, Jay-Z and Beyonce, Ben Affleckalso made the list.
8. Sturgill Simpson “Metamodern Sounds in Country Music” (High Top Mountain) A throwback progressive hunkered down with a whip-smart band: country music has seen this before. But on his breakthrough second album, Sturgill Simpson made it a pliable trademark, grounded at every turn by his winning, seen-it-all baritone.
PRICE PER SQUARE FOOT: $667
Influenza neuraminidase: A druggable target for natural products
Are you often irritable?
3) I am often irritated 0 1 2 3 4
Employment is crucial to ensuring people’s well-being. We will focus our efforts on facilitating employment to see that through their hard work, people can create wealth and realize their full potential.
Granted, it is easier to remake something than to make something new. Anyone who has faced a blank page knows that. But if fashion’s ubiquitous default to the 1960s over the last seven years has exposed anything, it is its own lack of imagination, not only about clothes and consumers, but about the relationship of culture and dress.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
用户在百度搜索平台上最常点阅的新闻事件是，为纪念二战胜利70周年于9月3日在北京举行的阅兵仪式。在此次庆祝活动中，上万名军人接受了现任国家主席习近平、前任主席胡锦涛和江泽民，以及多位外国领导人的检阅，其中包括俄罗斯总统弗拉基米尔·V·普京(Vladimir V. Putin)。
"I want to tell you what happened I opened the envelope and it said Emma Stone, La La Land and that is why I took such a long look at Faye and at you. I wasn't trying to be funny. This is Moonlight for best picture," Beatty told the shocked crowd as he explained the blunder.
The role of biosensors in the detection of emerging infectious diseases
法国巴黎高等商学院排名第二，尽管该学院在除MBA以外的所有排名中都胜过伦敦商学院。法国巴黎高等商学院最终不敌伦敦商学院的原因是，其高管MBA课程Trium是与伦敦经济学院(London School of Economics)和纽约斯特恩商学院(Stern School of Business)合办的，因此这门课程在该项排名中的得分只有总得分的三分之一。（合办课程的商学院参与EMBA课程排名时按比例获得分值。）
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Officials with the State Administration of Press, Publication, Radio, Film and Television (SAPPRFT) said the film industry in China kept a steady development momentum in 2016 amid the "new normal" of the country's economic development.
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
他在最后一刻选择了教育慈善机构Teach First，后者如今已经成为英国招聘新毕业生最多的机构。雷文斯克罗夫特没有空降至需要重组的公司，而是开始在波尔主教学校(Cardinal Pole School)教授商业和经济学，该校主要招收伦敦东部哈克尼区(Hackney)11岁至19岁之间的青少年。
But the declines continued, and now it’s all over, red rover.
法国兴业银行(Societe Generale)国际策略师基特?朱克斯(Kit Juckes)说，过去30年破灭的三个世界级金融大泡沫背后，都是“美联储(Fed)太久时间将政策利率维持在名义经济增长率之下”。
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
The latest survey also showed the country had a narrower gap between genders in 2015. As to the structure of genders, the male-to-female ratio last year was 105.02, lower than the 2010 ratio of 105.2.
The very best bosses I’ve seen are passionate about their work; they live and breathe their jobs and strive to do the best work possible. Yet at the same time, they have lives outside of work. They understand the need to balance family and work or play and work. And they set a good example of how to do that for their employees。
Despite such arguments from a handful of scientists, the vast majority of those who study the climate say the earth is in a long-term warming trend that is profoundly threatening and caused almost entirely by human activity.
The four megalopolises also saw fewer traffic jams after November due to reasons ranging from less travel in winter and smoggy days to the return of migrant workers to their hometowns.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Yet institutions matter, too, because they set the rules of the game.
Inhibition of SARS coronavirus helicase by bismuth complexes
For starters, breaches like that of Bitstamp and the much larger (valued at about $400 million at the time) 2011 hack of the exchange Mt. Gox are often misconstrued as security issues with the currency itself. But they are only signs of flaws in those particular exchanges and not a sign of an issue with the underlying technology. And it is the underlying technology behind bitcoin that most excites. As we wrote in the “Shape the Future” package of our January 2015 issue, most of the vocal enthusiasts so bullish on bitcoin—from big-name entrepreneurs like Marc Andreessen to the developers and miners who spend their days refreshing the bitcoin Reddit page—are more interested in the applications that can be built on bitcoin’s “block chain,” the currency’s foundational backbone, than they are in bitcoin as a monetary system. The block chain allows the secure exchange of any form of value between two entities.
New Year comes but once a year. But when it comes it brings good cheer.新年一年只有一次，但每次来临都带来喜悦。
10. 《结果》(Results)，导演：安德鲁·布西内斯克(Andrew Bujalski)。
The Baltic Dry index, a measure of the trade in bulk commodities, has been touching historic lows. China, which in 2014 overtook the US as the biggest trading nation, this month reported double-digit falls in both exports and imports in January. In Brazil, which is experiencing its worst recession in more than a century, imports from China have collapsed.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Common 和 Day 将会演绎电影《马歇尔》中的歌曲《Stand Up For Something》还有Settle会演唱电影《马戏之王》中的歌曲《Thisis me》。
WTF.2: They Believe You Can Fly
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
这段深入11岁女孩心灵与情感的旅程可能是皮克斯迄今最疯狂的冒险。这是一部非常有趣的工作场合情景喜剧，艾米·波勒(Amy Poehler)、菲利丝·史密斯(Phyllis Smith)和敏迪·卡灵(Mindy Kaling)等人带来了精彩感人的演出，这是一则关于心理发展的精巧语言，也是对于悲伤在我们的生活中所扮演的角色的一种感人而诚恳的辩护。
Rounding out the top three is Fleetwood Mac at $59.5 million. Though the band contains three men, it also boasts two high-profile ladies—Stevie Nicks and the recently-returned Christine McVie—rendering the group eligible for this list. Its On With The Show tour included 86 concerts during our scoring period, grossing well over $1 million per city.
Isolated in northern China, this virus was similar to the virus that spread before 1957. For this reason, individuals born before 1957 were generally protected, however children and young adults born after that year were not because they had no prior immunity. By January 1978, the virus had spread around the world, including the United States. Because illness occurred primarily in children, this event was not considered a true pandemic. Vaccine containing this virus was not produced in time for the 1977-78 season, but the virus was included in the 1978-79 vaccine.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
5. Gross warns: 'Ponzi Scheme! Tipping Point! Credit Supernova!'
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Confidence and a good elevator speech can take any pitch to the next level. The first marketing any company experiences comes from its founder. Spend time learning how to share your vision without coming across as “salesy.” Don’t be afraid to ask for the sale, but remember: the client is always the focus.
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
It also said 98 percent of government-sponsored students returned to China. Government-sponsored students who study abroad have chosen to pursue disciplines most needed in China, including engineering, the pure sciences, agriculture and medical science.
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Recognize me?: image via blog.discoverymagazine.com
Well, at least Hilary has won something this year. I'm sure she's thrilled.
Before becoming Germany's top trading partner, China was Germany's largest trading market in Asia. Germany has been China's top trading partner in the European Union for the last 2 years.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
The post came after anonymous Internet users alleged that some questions and answers on the National Postgraduate Entrance Examination, which was held on Saturday and Sunday, were released in advance.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
This was the biggest monthly drop in imports since last September and also means shipments have contracted year-on-year for the past 15 months straight.
Her predecessor David Cameron placed fifth in CNNMoney's previous ranking in March 2015 with his salary of ￡142,500, then worth $214,800. May is only seventh.
通用汽车公司（General Motors）帮助改善了大峡谷州的就业前景。今年3月，这家汽车制造商宣布，计划在凤凰城郊区钱德勒建设该公司的第四座信息技术创新中心。通用汽车预计将雇佣1,000名员工，主要包括为这座新中心效力的软件开发人员、数据库管理员和系统分析师。通用汽车公司首席信息官兰迪?莫特（Randy Mott）在新闻稿中宣布了这个举措，他表示，“大凤凰城地区是出色的枢纽，吸引了新兴技术人才——从大学毕业生到职场专业人士。”
Whether China opens the stock floodgates or not will be a major price-driver in cotton and sugar — and potentially also in corn, soyabean or vegetable oil — markets in 2017, the bank said in its report.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
In Canada, we live the privileged life, with plenty of food, water and shelter—we have watches, bicycles, computers and television sets. 在加拿大，他们过着特权般的生活，他们有很多食物、房子和水。他们拥有很多手表，汽车，各种电器和奢侈品。
当芬兰程序员Jerry Jalava 2008年遇到车祸，他面临双重悲剧。首先，他失去了他的手指，对于靠打字生存的人来说是个大问题。其次，他必须跟一个幽默感过剩的医疗小组打交道。了解了他的遭遇后，一位外科医生竟然提议Jalava应该出门去买个“USB手指驱动器”。
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Talking about wanting to kill your boss may not be that uncommon, but it does put a damper on things when said boss actually ends up murdered. When the police came to ask questions, they ended up learning that the Cranston brothers had recently resigned to ride their motorcycles cross-country. Until they could be cleared, the two men were both suspects.
Complying with the law may prove challenging, even if improvements ultimately reduce long-term costs. In addition, 2015 is the deadline for buildings to convert from No. 6 heating oil to No. 4 oil, which is less polluting.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Warm hearted wishes for a happy New Year filled with all your favorite things.传统佳节之际，献上殷殷祝福，祝新年万事如意！
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
A modular microarray imaging system for highly specific COVID-19 antibody testing
It adds up to a pointed reminder that Her Royal Swiftness can reclaim her place at pop's cutting edge whenever she feels like it.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
If you do much hiring of freelancers, you’ve probably considered outsourcing the outsourcing. There are several great services that can help, each with varying business models. For example, Bolton Remotewill build your team with vetted, offshore contractors. Another provider,Hubstaff, starts with your project in mind and then matches you with project specialists. Using an outsourcing placement service will save time instead of trying to do the recruiting yourself. These firms typically offer free recruiting and placement services but take a cut of the hourly rate.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Wages will finally accelerate after years of stagnation
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Company: (Wonderbag) Natural Balance
The research also suggests there maybe a value in finding a job through an internship. Interns who accepted a job offer had higher salaries than those who had received an offer but refused it. Those interns who did not receive an offer had lower salaries still. The gap between these groups had increased three years after graduation.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
The excavators think the cemetery datesback around 1,700 years, to a time when Kucha was vital to controlling the Western Frontiers (Xiyu) of China. Since the SilkRoad trade routes passed through the Western Frontiers, control of this key region was important to China's rulers.
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
With the Russian rouble depreciating against other major currencies, there has been an increase in visitors to this country in recent years.
Friends count too
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
A facile assay for rapid detection of COVID-19 antibodies
但是我们波士士顿波士顿咨询集团不认为中国本次改革会导致中国经济不稳定。我们相信中国经济在习主席的领导下会持续高速增长。我们相信上个星期的改革（三中全会）会确保中国经济从现在一直增长到（至少）2020年。根据我们已掌握的资料，我们预测中国经济在未来10年会增加4万亿美金(而书中说是6.4万亿。2012中国GDP为8.3万亿美金)。如果加上印度，亚洲两大国未来的增长总量会达到10万亿美金。在此期间，中产阶级会迅速膨胀，进而增强对经济增长的乐观态度。当然，没有人能完美地预测未来，在我们的近期的一本关于中国和印度经济发展的书中（《Trillion Prize:Captivating the Newly Affluent in China and India》），我们也描述了一些经济增长缓慢的例子。不过总体上我们还是对中国的未来保持乐观态度。
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Best wishes for the holidays and happiness throughout the New Year.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
7The United States
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
14. Google Calendar
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
“…did a song and dance routine in hopes of getting the job.”
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Anti-HIV drug repurposing against SARS-CoV-2
The Lego Batman Movie
Length-scale dependence of protein hydration-shell density
The issue has also hit Beijing’s efforts to secure market economy status in the WTO, which it claims it will be entitled to automatically on December’s 15th anniversary of it joining. If China obtains that status it could affect the ability of the US and others to bring anti-dumping cases, as it would remove their ability to use prices in third countries for comparison.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
We will speed up the reform of SOEs and state capital.
In an interview with Yicai magazine last week, the chairman of China Construction Bank pointed to the rising tide of non-performing loans as the biggest problem confronting China’s banks.
About this collection
2. Staying too long in a job that you want to leave
The base hopes to keep up public awareness of pandas and the necessity of conservation of their natural habitats while Increasing the wild population by reintroducing individuals into areas in China where populations have declined.